Course Syllabus for English-Taught Majors

The Teaching Syllabus forFrontiers of Biomedical Engineering

Course Code: 09041020

Course Category: major elective

Majors: Chemistry; Chemical Engineering and Technology

Semester: Spring

Total Hours: 36 Hours         Credit: 2

Lecture Hours: 36 Hours         

Instructor: Qian Yu

Textbook: W. Mark Saltzman,Biomedical Engineering: Bridging Medicine and TechnologyCambridge university press (ISBN-13 978-0-521-84099-6), 2009.

References:

[1] Introduction to Biomedical Engineering, Edited by J. D. Enderle, S. M. Blanchard and J. D. Bronzino, Translated by Feng Zhouyan, Publisher: China Machine Press, ISBN-13: 978-7111458784, 2010.

[2] Biomedical Engineering, Edited by Deng Yulin, Publisher: Science Press, ISBN: 978- 7030201928, 2007.

[3] Biomedical Materials, Edited by Zheng Yufeng and Li Li, Publisher: Harbin Institute of Technology Press; ISBN-13: 978-7561226773, 2005.

[4] Biochemistry, Edited by Wang Jingyan, Zhu Shenggeng and Xu Changfa, Publisher: Higher Education Press (CHEP), ISBN-13: 978-7117096270, 2004.

 [5] Biomedical Engineering: Bridging Medicine and Technology, Edited by W.M. Saltzman, Publisher: Cambridge University Press (CUP), ISBN-13: 978-1107037199, 2009.

[6] Modern molecular biology, Edited by Zhu Yuxian, Li Yi and Zheng Xiaofeng, Publisher: Higher Education Press (CHEP), ISBN-13: 978-7040222142, 2011.

[7] Modern Biochemical Engineering Series: Biomedical Engineering, Edited by Liu Changsheng, Publisher: East China University of Science and Technology Press, ISBN-13: 978-7562831952, 2012.

Teaching Aim:

Biomedical Engineering (BME for short) is an interdiscipline containing science, engineering and medicine which multi-level study the structure and function of human body and all kinds of life phenomena applying the principles and methods of natural science and modern engineering technology. Its application technology is mainly used for materials, products, instruments and system of prevention, diagnosis, monitoring, treatment, health care and rehabilitation of human disease. At present, the biomedical engineering has become the important foundation and pillar discipline in the field of current medical, and it has important strategic significance on the improvement of human health and quality of life and the development of the national economy. By the studying of the course, the student can gain some understanding of the basic concepts, the development history, the relevant theoretical basis, the current main research direction and application field and future development trend of this new discipline. The teaching of this course will broaden the student's professional horizons, arouse their interest in the field of scientific research, lay a solid foundation for working on the biological materials, health care, medical diagnosis and testing industry in the future.

Chapter I: INTRODUCTION OF BIOMEDICAL ENGINEERING

Lesson period: 2 weeks, 4 periods in total

Essentials of Teaching: Grasp the concept of biomedical engineering; Be acquainted with the modern development history of biomedical engineering; Be acquainted with the major topics in the research of BME and the development trend of current biomedical engineering research.

Teaching Contents

1.1   Introduction of biomedical engineering

1.2   The development history of biomedical engineering

1.3   Biological foundation

1.3.1 Protein

1.3.2 DNA

1.3.3 Cell and tissue

1.4   The development trend of biomedical engineering in the future

Problems:

1.Understand the basic concepts of biomedical engineering.

2.Understand the structures and functions of common biological molecules and basic theory of cytology.

 

 

Chapter II: GENE ENGINEERING AND CELL CULTURE

Lesson period: 3 weeks, 6 periods in total

Essentials of Teaching: Understand the basic principles of molecular biology related to gene engineering; Be acquainted with the commonly used cell culture methods and application fields; Understand the basic knowledge of bioinformatics and cell communication.

Teaching Contents

2.1   Gene engineering

2.1.1 Basic molecular structure of DNA and RNA

2.1.2 Main support technology of gene engineering

2.1.3 Human genome project

2.2   Cell culture

2.2.1 Basic knowledge of cell and cell culture methods

2.2.2 Main application fields for cell culture

2.3   Genome biotechnology

2.3.1 DNA sequencing technology

2.3.2 The building of DNA database

2.3.3 DNA amplification technique in vitro (PCR)

2.3.4 Separation technology of gene from functional protein

2.4   Bioinformatics

2.4.1 Development course and main research direction of bioinformatics

2.4.2 The main databases of bioinformatics

Problems:

3. Understand the common genome biotechnology.

4. Understand the development history of the human genome project through literature review.

Chapter III: BIOMOLECULE ENGINEERING AND BIOMATERIALS

Lesson period: 4 weeks, 8 periods in total

Essentials of Teaching: Let students be familiar with the basic concept of biomolecule engineering, understand the basic knowledge of immunology and the state of the development of immune engineering, and understand the category of biomaterials. Encourage the student to consult relevant literature, to understand the latest surface modification method of biomedical materials, increasing the interaction between the teacher and students, and enriching teaching contents.

 

Teaching contents

3.1   Types and characteristics of biological molecules

3.1.1 Sugars

3.1.2 Lipids

3.1.3 Amino acids

3.2   Immunology and immune engineering

3.2.1 Brief development history of immunology

3.3.2 Major immunological detection methods

3.3.3 Development and applications of immune engineering

3.3   Summary of biomedical materials

3.3.1 The characteristics and classifications of biomedical materials

3.3.2 Interactions between materials and biological tissues

3.3.3 The biological evaluation standard and experimental methods of biomedical materials

3.3.4 The development trend of biomedical materials

3.4   Surface modification of biomedical materials

3.4.1 The mechanical surface modification of the biomedical materials

3.4.2 The physical surface modification of biomedical materials

3.4.3 The chemical surface modification rule biomedical materials

Problems:

5.Be familiar with the structure characteristics and physiological functions of several kinds of common biological molecules.

6.Understand the main immunological detection methods.

7.Understand the types of biomedical materials.

8.Consult relevant professional literature and briefly evaluate the research status of the surface modification methods of one kind of biomedical materials.

Chapter IV: PHYSIOLOGY AND BIOMECHANICS

Lesson period: 4 weeks, 8 periods in total

Essentials of Teaching: Understand the basic knowledge of human physiology, and the related physiological characteristics and functions of cardiovascular, kidney, and bone tissue. Understand the applications of the basic engineering principles in various kinds of biological structures and the development of clinical application. Encourage students themselves to consult the relevant information and understand the latest research in the related field.

 

Teaching contents

4.1   Cardiovascular physiology

4.1.1 The biological electrical activity of the heart and cardiac pump function

4.1.2 The regulation of cardiovascular activity

4.1.3 The flowing properties of blood

4.1.4 Hemodynamics in the heart, arteries and veins

4.2 Renal physiology

4.2.1 The main structure and functions of kidney

4.2.2 Glomerular filtration function

4.2.3 Reabsorption and secretion of renal tubular

4.3 Bone tissue physiology

4.3.1 The basic mechanical properties of bone materials

4.2.2 Functional adaptation of bone

4.4 Summary of biomechanics

4.4.1 The basic knowledge of mechanics of materials

4.4.2 The brief development history and research contents of biomechanics

4.4.3 Research methods of biomechanics

4.4.2 The application of kinematics theory and dynamics theory in biomechanics

Problems:

9. Understand the basic structure and functional characteristics of the cardiovascular system.

10.Understand the structure and physiological functions of the kidney.

11.Understand the structure, physical and chemical properties and mechanical properties of bone materials.

12.Understand several kinds of research methods of biomechanics and be able to familiar with a certain specific research method by combining with the instance.

 

 

Chapter V: BIOLOGICAL IMAGING AND TISSUE ENGINEERING

Lesson period: 3 weeks, 6 periods in total

Essentials of Teaching: Understand the commonly used medical imaging technology, characteristics, and their respective advantages and disadvantages. Be familiar with the basic concept of tissue engineering as well as the physiological basis of human tissues. Encourage students to understand common biomedical materials related to tissue engineering through literature review.

 

Teaching contents

5.1   Modern biological imaging technology

5.1.1 Overview

5.1.2 Projection X-ray imaging

5.1.3 X-ray computed tomography

5.1.4 Ultrasonic imaging technology

5.1.5 Radionuclide imaging system

5.1.6 Nuclear magnetic resonance (NMR) imaging system

5.1.7 The future development of biological imaging technology

5.2   Foundation of tissue engineering

5.2.1 Composition, classification and structure of human tissue

5.2.2 Basic elements of tissue engineering

5.2.3 Application fields of tissue engineering

5.2.4 Functional tissue engineering

5.3   Biomedical materials related to tissue engineering

5.3.1 Overview

5.3.2 Preparation technique of tissue engineering scaffolds

5.3.3 Biomedical materials related to tissue engineering of structural classes

5.3.4 Biomedical materials related to tissue engineering of metabolism classes

 

Problems:

13. Be familiar with above 3 kinds of biological imaging technologies and their respective advantages and disadvantages.

14. Understand the development history of tissue engineering and the outlook for its future development trend by combining with related literature.

15. Consult relevant literature and be familiar with the preparation and properties of at least one kind of biomedical materials related to tissue engineering.

 

 

Chapter VI: BIOMEDICAL ENGINEER

Lesson period: 2 weeks, 4 periods in total

Essentials of Teaching: Understand the range of applications of biomedical engineering in clinical field. By guiding students to consult the latest related literature and class discussion, make them understand the present situation of research and future development trend of biomedical engineering in the field of cancer treatments and artificial organs.

 

Teaching contents

6.1   A brief introduction of biomedical engineer

6.2   Application of biomedical engineering in the field of cancer treatment

6.2.1 Operative treatment

6.2.2 Chemotherapy

6.2.3 Radiotherapy

6.3.4 Naturopathy

6.3   Application of biomedical engineering in the field of artificial organs

6.3.1 Mechanical artificial organs

6.3.2 Half mechanical artificial organs

6.3.3 Biological artificial organs

6.3.4 Organ transplantation and individualized artificial organs

 

Problems:

16.  Be familiar with common cancer treatment methods and compare their advantages and disadvantages.

17.  Refer to related documents and be familiar with two or more of the characteristics of artificial organs.

18.  Refer to related documents and discuss the problems and possible solutions of organ transplantation at present.

 

 

Assessment Methods: Oral presentation

 

 

 

                                Written by: Qian Yu

 

                                 2014-10-24